Animal models rats, mice, pigs and dogs animal models were reported for colon targeted drug delivery systems. Thanks for helping us catch any problems with articles on deepdyve. Review article colon targeted drug delivery using different approaches sharma anuj, jain k amit. Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. In recent years, the global pharmaceutical market for biologics has. Drugs such as proteins and peptides that are known.
Colon targeting colonic drug delivery uses pharmacology study material project thesis title pharmacology lectures for pharmacy students pharmacology easy notes, kaplan pharmacology lecture notes pdf, pharmacology lecture notes ppt. Colonic drug delivery has gained increased importance not. Colonic drug targeting approaches for treatment of. Colonic drug targeting approaches for treatment of inflammatory bowel disease. Colonspecific drug delivery systems cdds are desirable for the treatment of a range of local. Colon targeting colonic drug delivery uses pharmacology. Advances in oral nanodelivery systems for colon targeted. Jun, 2015 colonspecific drug delivery systems cdds are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohns disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer.
Pharmaceutics free fulltext strategic approaches for. Review article colontargeted oral drug delivery systems core. Introduction the aim of targeted drug delivery tdd is selective and effective localization of drug into the target at therapeutic concentrations with limited or no access to non target sites. Moreover, the resident microflora could also affect colonic performance via degradation of the drug. Colon targeted drug delivery systems the pharma innovation journal. Review on recent and novel approaches to colon targeted drug. To achieve successful colonic delivery, a drug needs to be protected from. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. Diet, diseased state, and food intake influences the ph of the gastrointestinal fluid.
Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. The concentration of drug reaching the colon depends on formulation factors, the extent of retrograde spreading and the retention time2. It is the type of drug targeting wh erein the drug is int racellularly localized at the target site via endocytosis or through receptorbased ligand mediated entry 3. New approaches to use nanoparticles for treatment of. Targeted therapy drugs for colorectal cancer as researchers have learned more about the gene and protein changes in cells that cause colorectal cancer, they have developed newer drugs to specifically target these changes. An oral colonic drug delivery system must allow zero or minimal drug release within the conditions and times pertaining in the stomach and small intestine before allowing release in the colon. The ms significantly increased the area under the curve and mean residence time by 1. Targeted drug delivery implies selective and effective localization of drug into the. It also showed prolonged and preferential adhesion to rat colonic mucosa, as well as expedited degradation in presence of rat caecal contents. Colon targeted drug delivery systems have gained a great deal of. Number of serious diseases of the colon might be capable of being treated more effectively if drugs were targeted on the colon.
The colon targeted drug delivery system is used for the treatment of various diseases related to colon like inflammatory bowel disease, crohns disease, colon cancer, etc. Strategic approaches for colon targeted drug delivery mdpi. Nemade mahesh s, chaudhari rajesh y, and patil vijay r. Colon drug delivery, crohns disease, inflammatory bowel disease. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like crohns disease, ulcerative colitis, irritable bowel syndrome and constipation but also for. Review article colon targeted drug delivery systems.
However, the most important application of targeted drug delivery is to treat cancerous tumors. However, nanotechnological approaches could also be adapted to crohns disease by targeting drugloaded nanoparticles to both the small intestine an additional site of this disease and the large intestine. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and. Rajpurohit, et al polymers for colon targeted drug delivery the colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Pharmaceutics free fulltext phospholipidbased prodrugs.
Rheological characterization of the hydrogel formation and the hydrogel network. The ph of the gi tract is subject to both inter and intra subject variations. The results of the study show that matrix tablets containing 20% of guar gum are most likely to provide targeting of nitrofurantoin in the colon. Nov 21, 2017 colon targeting colonic drug delivery uses pharmacology study material project thesis title pharmacology lectures for pharmacy students pharmacology easy notes, kaplan pharmacology lecture notes pdf, pharmacology lecture notes ppt, pharmacology notes for medical students. Colontargeting of progesterone using hybrid polymeric. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the. Precise delivery would result in minimized drug loss due to enzymatic activities of the distal colon. Occurrence of inflammatory bowel diseases has increased at an alarming rate. Colon targeting diseases, drugs and sites target sites disease conditions drug and active agents topical action local action systemic action inflammatory bowel diseases. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non colonic conditions. After decades, progress against an undruggable cancer target. When studies were continued in colonic fluids, matrix tablets released almost 100% drug. Novel colon targeted drug delivery system using natural polymers.
Pharmaceutical approaches to colon targeted drug delivery. Drugs that undergo extensive first pass metabolism. Colon targeted drug delivery, nitrofurantoin, invitro dissolution, guar gum, rat caecal content. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like crohns disease, ulcerative colitis, etc. Drug targeting to the colonic area is not only associated with the treatment of colonic ailment locally but also delivering drugs such as protein and peptide for their systemic effects which are degraded and bioavailability is very depressed due to the instability in the gi tract. Amgens drug, amg510, targets a second groove in the same kras protein. Colon targeting holds a great potential and still need more innovative work. Colon targeting is naturally of value for the topical treatment of diseases of colon such as chrons diseases, ulcerative colitis, colorectal cancer and amebiasis. The potential of pectin as carriers for colonic drug delivery has been demonstrated previously hiorth et al. Polymers for colon targeted drug delivery pharmaquest. Novel approaches to colon targeted drug delivery system.
Amidated pectin hydrogel beads for colonic drug deliveryan. In this work, we present a novel phospholipid plbased prodrug approach, as a tool for colonic drug targeting in uc. Thesis effective if the drug substances were targeted directly on the site of action in the colon. Tailoring of drug delivery of 5fluorouracil to the colon via a mixed. Various pharmaceutical approaches to colon targeted drug delivery systems.
Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. For simulating the human physiological environment of the colon, appropriate animal model selection is depends on its approach and design of system. Successful oral colonic delivery first requires that the drug or drug system reach the proximal colon at a precise time. In a hydrogel system, the success at preventing drug release will depend on the drug solubility, its diffusional. Colonic epithelial permeability modified by enhancers.
The concept of using ph as a rigger to release a drug in the colon is based on the ph conditions that vary continuously down the gastrointestinal tract. Introduction targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, crohns disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. A variety of drugs can be used to counteract colon diseases endowing different site actions as shown in the table 1 reddy et al. Colon drug delivery system authorstream presentation. Colon targeted drug delivery systems a potential approach nishant singh and dr. Colon targeted drug delivery system a novel perspective by bhushan prabhakar kolte. Its colonic delivery offers a number of advantages, such as prevention of its adverse gastric effects, targeting to its site of action, for example if the drug is developed for its preventive action in colon cancer jasmeet and nath, 2010, kaur saini et al. The outlook for new treatment strategies in crc management is also underlined.
Formulation development and evaluation of drug release. Nanoparticlebased oral drug delivery systems targeting the. Gastro intestinal transit time gastro intestinal transit time. Colon targeted drug delivery system may be following the concept of control or sustained route for drug administration has received more attention vinay et al. New systems and technologies have been developed for colon targeting and to overcome pervious methods limitations. Drug absorption in the colon drug absorption in the colon. Current oral nanodelivery system strategies for drug delivery to inflamed colon. Nanoarchitectonics for smart delivery and drug targeting. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, crohns disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. The changes in the ph along the gastrointestinal tract have been used as a means for targeted colon drug delivery. Times dependent drug delivery systems have been devel oped that are based on the principle to prevent release of drug until 34 h after leaving the stomach.
Many other researchers have also been challenging the same subject. Hence great potential lies in the development of colon targeted drug delivery system for formulations of herbal drugs. Significant progress has been made toward developing a truly selective drug delivery system that targets the site of inflammation in uc. Drug targeting to the colonic area is not only associated with the treatment. Drugs used for local effects in colon against git diseases. Hamzehzadeh l, imanparast a, tajbakhsh a, rezaee m, pasdar a. That appears to make it more potent and specific than wellsprings compound, the company reports this week in nature. Treatment of colon can be made effective if the drug can be targeted directly into the colon because drug release and absorption should not be take in abdomen and the small intestine and bioactive agents should not be degraded and to allow drug release into the colon. Oct 01, 2008 read a new concept in colonic drug targeting. Introduction over decades, colon targeted drug delivery systems have been gaining significant attention not just for providing more effective therapy to. Nanoparticlebased oral drug delivery systems targeting the colon for treatment of ulcerative colitis article pdf available in inflammatory bowel diseases 247 may 2018 with 1,012 reads.
Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. The research on colon targeting has been driven primarily by the need to improve. Targeted drug delivery can be used to treat many diseases, such as the cardiovascular diseases and diabetes. Target sites disease conditions drug and their active ingredients 1 topical action inflammatory bowel. Colon targeted drug delivery systems a potential approach. Some of them are, ph dependent, time controlled, prodrug. To achieve successful colon targeted drug delivery, a drug need to be protected from.
Pdf nanoparticlebased oral drug delivery systems targeting. Pdf colonic drug delivery of new approaches researchgate. Colon specific drug delivery systems cdds are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohns disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. This targeting of drug to the disease site lowers the. Emerging techniques and challenges in colon drug delivery. Colon, gastrointestinal tract, crohns disease, biodegradable polymers. Pdf day by day there are new developments in field of colon specific drug. For the successful targeting of drugs to colon the dosage form should be designed such that it prevents the drug release in upper git and releasing it in the colonic region. Different approaches jose s, dhanya k, cinu ta, litty j, chacko aj. For example, guinea pigs have glycosidase and glucuronidase. Colon targeting is a comparatively new approach for the localized delivery of drugs to obtain maximum possible output for the treatment of ailments.
Summary background current approaches to colonic drug delivery exploit one of two main physiological characteristics. Drug targeting to colon is also useful when a delay in drug absorption is desired from therapeutic point of view, such as treatment of diseases that have peak symptoms in the early morning like nocturnal asthma, angina or arthritis 2,3. Integrated drug delivery for ulcerative colitis treatment. Day by day there are new developments in field of colon specific drug delivery system. In order to target a drug inside the body it is required to be in the form of a dosage form. Formulation optimization of colonic drug delivery systems chapter 1 nitesh n. The drug could bind in a nonspecific manner to dietary residues, intestinal secretions, mucus or general faecal matter, thereby reducing the concentration of free drug. In doing so, the passive method of targeting tumors takes advantage of the enhanced permeability and retention epr effect. It involves the formation of a covalent linkage between drug and carrier in such a manner that upon oral administration the moiety remains intact in the stomach and small intestine. In ulcerative colitis uc, the inflammation is localized in the colon, and one of the successful strategies for colon targeting drug delivery is the prodrug approach. The prod rugapproach to colonic delivery is currently used to treat inflammatory bowel diseases ibd, in which active drugs are liberated by the action of bacterial enzymes such as azoreductase, glucosidases, and glucronidases in the colon friend, 1992. Colon targeted drug delivery differs from ordinary enteric coatings that are designed to merely avoid drug release in the stomach in that the tablet or capsule is specially formulated to channel greater quantity of drug release to the colonic compartment, thus preventing or highly reducing drug release until the dosage form reaches the colon.
We aim to use the phospholipase a2 pla2, an enzyme that is overexpressed in the inflamed colonic tissues of. The challenge of targeting drugs to the colon part of the gi tract has been embraced by scientists over the past two decades. At least 50% of the dosage forms available in the market are oral dosage form because these system have more advantage due to high patient compliances akhil et al. Improved oral drug delivery design has drastically improved the colonic bioavailability of drugs, that is, these formulations are effective at reaching and releasing drug specifically in the colon. Colon targeting, colon targeted drug delivery, targeted drug delivery, drug delivery, colon.
Aside from drug solubility, the stability of the drug in the colonic environment is a further factor that warrants attention. Formulation and evaluation of colon targeted drug delivery system. Inulin hydrogels as carriers for colonic drug targeting. Formulation and evaluation of colon targeted drug delivery. Several factors will affect colon targeting which generally include physiological factors and. Lower doses might be adequate and, if so, systemic side effects might be reduced. Pdf role of natural polymers in the development of. After mice with several types of tumors with krasg12c were given sufficient doses of the drug alone or in combination with other drugs, most tumors. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like crohns disease, ulcerative colitis. M college of pharmacy, bahadurgarh, haryana, india day by day there are new developments in field of colon specific drug delivery system. The predominant inflammatory bowel diseases are ulcerative colitis and crohns disease.
1135 1571 753 1456 131 320 715 593 612 1231 470 287 945 1178 411 944 664 708 111 1197 752 1373 958 469 710 429 217 103 277 881 1344 1070 1467 521 850